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DPYD genotype

Genetic tests · also printed as DPYD, DPYD genotype, DPD deficiency, DPYD variant, DPD genotype

Typical UK adult rangeExpected result: Not detected

No variant detected is the usual result.

What this test measures

The DPYD test looks for inherited variants in the enzyme that breaks down some chemotherapy medicines (fluoropyrimidines). It is required in the UK before those medicines are given.

Why doctors request it

Tested once before chemotherapy with capecitabine or 5-fluorouracil.

What commonly pushes it up

Carrying one or two reduced-function variants, which about one person in twenty does

What commonly pushes it down

Not applicable

Everyday reasons for a value outside the range

A result is fixed for life and only needs testing once

About the sample

No fasting needed.

Written by a UK consultant physician. Typical UK adult reference ranges; your laboratory's own printed range takes precedence.

Got a report with DPYD genotype on it?

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This is an educational summary of results you uploaded. It is not medical advice, a diagnosis or a treatment plan, and it does not replace the doctor who requested the test. If you are worried, or a result is marked outside range, discuss it with your doctor. Written and reviewed by a UK consultant physician. Reference ranges vary between laboratories.